santacruz GSK-3 Inhibitor X


santacruz GSK-3 Inhibitor X
santacruz GSK-3 Inhibitor X

GSK-3 Inhibitor X (CAS 740841-15-0)

5 5santacruz GSK-3 Inhibitor Xsantacruz GSK-3 Inhibitor Xsantacruz GSK-3 Inhibitor Xsantacruz GSK-3 Inhibitor Xsantacruz GSK-3 Inhibitor X (Based on popularity) 1

santacruz GSK-3 Inhibitor X

Synonym: BIO-Acetoxime; 6-Bromoindirubin-3′-acetoxime, BIA
Application: A selective GSK-3α/β inhibitor
CAS Number: 740841-15-0
Purity: ≥95%
Molecular Weight: 398.21
Molecular Formula: C18H12BrN3O3
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information

Product Name Catalog # Unit Price Qty Add Favorites
GSK-3 Inhibitor X sc-221689 1 mg $115   Add  


GSK-3 Inhibitor X is an acetoxime analog of BIO which acts as a selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). GSK-3 Inhibitor X induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Technical Information

Physical State: Solid
Solubility: Soluble in DMSO (10 mg/ml).
Storage: Store at 4° C
Melting Point: 236.83 °C (Predicted)
Boiling Point: 551.87 °C (Predicted)
Density: 1.69 g/cm3 (Predicted)
Refractive Index: n20D 1.74 (Predicted)
IC50: GSK-3α/β: IC50 = 10 nM; Cdk5/p25: IC50 = 2.4 µM; Cdk2/A: IC50 = 4.3 µM; Cdk1/B: IC50 = 63 µM; Cdk4/D1: IC50 = ≥10 µM; aryl hydrocarbon receptor: EC5050 = ≥0.1 µM (yeast); aryl hydrocarbon receptor: EC5050 = 0.16 µM (mammalian)
pK Values: pKa: 9.23 (Predicted)

Safety and Reference Information

PubChem CID: 6538818
MDL Number: MFCD09037533

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.