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Alkyne-PEG3-COOH is a bifunctional triethyleneglycol derivative bearing a carboxy group, and an alkyne moiety. The former can be activated with peptide coupling reagents like PyBOP or carbodiimides like EDC to form a stable amide linkage with amines. The alkyne group can be coupled with azides in a CuAAc reaction.
PEGs are hydrophilic linkers that are useful in the synthesis of water soluble conjugates.
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Azide-PEG3-Amine
A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
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