MMP Green 基质金属蛋白酶绿色荧光底物 货号13519-AAT Bioquest荧光染料

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MMP Green 基质金属蛋白酶绿色荧光底物

MMP Green 基质金属蛋白酶绿色荧光底物

MMP Green 基质金属蛋白酶绿色荧光底物    货号13519 货号 13519 存储条件 在零下15度以下保存, 避免光照
规格 100 Tests 价格 2544
Ex (nm) 494 Em (nm) 515
分子量 ~2000 溶剂 DMSO
产品详细介绍

简要概述

产品基本信息

货号:13519

产品名称:MMP Green 基质金属蛋白酶绿色荧光底物

规格:100 Tests

储存条件:-15℃避光防潮

保质期:12个月

 

产品物理化学光谱特性

分子量:~2000

溶剂:DMF

激发波长(nm):494

发射波长(nm):515

 

产品介绍

基质金属蛋白酶(MMPs)是一个锌依赖性内肽酶家族,在细胞外基质中发挥作用。这些酶在负责结缔组织的分解,在骨重建、月经周期和组织损伤修复中起重要作用。虽然MMPs在某些病理过程中的确切作用尚不清楚,但MMPs似乎在关节炎以及肿瘤的侵袭和转移中起着关键作用。基质金属蛋白酶往往有多种基质,大多数家族成员都有能力降解不同类型的胶原蛋白以及弹性蛋白、明胶和纤连蛋白。很难找到对单一MMP酶有选择性的底物。该FRET底物被设计用于检测MMP酶的一般活性。当使用纯化的MMP酶时,它也可用于筛选MMP抑制剂。该FRET底物基于我们的tf/TQ2,MMP Green FRET由于tfi/TQ2 FRET对分离,FRET肽底物增加。荧光增强与MMP酶活性成正比。金畔生物是AAT Bioquest的中国代理商,为您提供最优质的MMP Green 基质金属蛋白酶绿色荧光底物。 

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图示

MMP Green 基质金属蛋白酶绿色荧光底物    货号13519

图1.内部淬火的FRET肽底物被蛋白酶消化以产生高荧光肽片段。荧光增强与蛋白酶活性成正比。

 

参考文献

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