柯胺G CAS 6472-91-9

	货号	23055	存储条件	在零下15度以下保存, 避免光照
	规格	5 mg	价格	984
	Ex (nm)	386	Em (nm)
	分子量	482.44	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：23055

产品名称：柯胺G

CAS：6472-91-9

规格：5mg

储存条件：-15℃避光防潮

保质期：24个月

产品物理化学光谱特性

分子量：482.44

溶剂：DMSO

激发波长(nm)：386

发射波长(nm)：N/A

产品介绍

Chrysamine G是刚果红的亲脂性双水杨酸类似物，具有高（Kd = 200 nM； Bmax = 1.13摩尔/摩尔Ab40）和低（Kd = 38.77 µM； Bmax = 23.10摩尔/摩尔Ab40）。 β-淀粉样蛋白（Ab）原纤维的亲和力结合位点。 它可以穿过血脑屏障，并可用作检测老年斑（Ab聚集体）的有用探针。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的柯胺G。 

参考文献

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
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Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brain
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Journal: Curr Pharm Des (2004): 1469

Amyloid binding ligands as Alzheimer’s disease therapies
Authors: Lee VM.
Journal: Neurobiol Aging (2002): 1039

Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice
Authors: Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H.
Journal: Neurosci Lett (2002): 5

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
Authors: Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, Hyman BT.
Journal: J Neuropathol Exp Neurol (2002): 797

Evaluation of 99mTc-MAMA-chrysamine G as an in vivo probe for amyloidosis
Authors: Dezutter NA, L and man WJ, Jager PL, de Groot TJ, Dupont PJ, Tooten PC, Zekarias B, Gruys E, Verbruggen AM.
Journal: Amyloid (2001): 202

In search of the ideal radiotracer for soft-tissue amyloid scanning
Authors: Lee VW, Shah NP.
Journal: Amyloid (2001): 220

In vitro affinity of 99Tcm-labelled N2S2 conjugates of chrysamine G for amyloid deposits of systemic amyloidosis
Authors: Dezutter NA, Sciot RM, de Groot TJ, Bormans GM, Verbruggen AM.
Journal: Nucl Med Commun (2001): 553

Inhibition of polyglutamine aggregation in R6/2 HD brain slices-complex dose-response profiles
Authors: Smith DL, Portier R, Woodman B, Hockly E, Mahal A, Klunk WE, Li XJ, Wanker E, Murray KD, Bates GP.
Journal: Neurobiol Dis (2001): 1017

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington’s disease therapy
Authors: Heiser V, Scherzinger E, Boeddrich A, Nordhoff E, Lurz R, Schugardt N, Lehrach H, Wanker EE.
Journal: Proc Natl Acad Sci U S A (2000): 6739