用于干细胞研究的小分子化合物

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用于干细胞研究的小分子化合物用于干细胞研究的小分子化合物

 


  Stemgent® 提供一系列独特的小分子–Stemolecules™ ,这类小分子可用于多能干细胞的自我更新和分化的主要信号通路的分析和调节,诱导多能干细胞(iPS)的细胞重编程,诱导和维持干细胞原始状态。

  Stemolecules™为保证高纯度(≥98%)进行了严格检测,通过NMR和质谱进行结构验证,并且测试了对干细胞的细胞毒性。Stemolecules™ 通常用于提高iPS细胞的产生和维持多能干细胞的培养。

 

Brand Name Catalog   Number Size
Stemolecule™ A83-01 04-0014 2 mg
04-0014-10 10 mg
Stemolecule™ ALK5   Inhibitor (RepSox) 04-0015 1 mg
Stemolecule™ All-Trans   Retinoic Acid 04-0021 100 mg
Stemolecule™ BI-D1870 04-0051 10 mg
Stemolecule™ BIO 04-0003 2 mg
Stemolecule™ BIX01294 04-0002 5 mg
Stemolecule™ CHIR99021 04-0004 2 mg
04-0004-10 10 mg
Stemolecule™ CHIR99021 in Solution 04-0004-02 2 mg (10 mM)
Stemolecule™ Cyclopamine 04-0022 2 mg
Stemolecule™ DAPT 04-0041 5 mg
Stemolecule™ Dorsomorphin 04-0024 2 mg
Stemolecule™ Doxycycline   hyclate 04-0016 10 mg
Stemolecule™ ec23 SRP002 5 mg
SRP002-2 2×5mg
Stemolecule™ Forskolin 04-0025 10 mg
Stemolecule™ GDC-0941 04-0047 5 mg
Stemolecule™ GSK429286A 04-0049 2 mg
Stemolecule™ IDE-2 04-0027 2 mg
Stemolecule™ KAAD-Cyclopamine 04-0028 100 μg
Stemolecule™ LDN-193189 04-0074 2 mg
04-0074-10 10 mg
Stemolecule™ LDN-193189   in Solution 04-0074-02 2 mg (10 mM)
Stemolecule™ LY411575 04-0054 5 mg
Stemolecule™ PD0325901 04-0006 2 mg
04-0006-10 10 mg
Stemolecule™ PD0325901  in Solution 04-0006-02 2 mg (10 mM)
Stemolecule™ PD173074 04-0008 2 mg
Stemolecule™ Purmorphamine 04-0009 5 mg
Stemolecule™ R(+)Bay  K 8644 04-0013 5 mg
Stemolecule™ RG108 04-0001 10 mg
Stemolecule™ SB431542 04-0010 5 mg
04-0010-10 10 mg
Stemolecule™ SB431542 in Solution 04-0010-05 5 mg (10 mM)
Stemolecule™ SB590885 04-0080 2 mg
Stemolecule™ SC1 (Pluripotin) 04-0011 1 mg
Stemolecule™ SHH Antagonist 04-0032 2 mg
Stemolecule™ Sodium Butyrate 04-0005 500 mg
Stemolecule™ Thiazovivin 04-0017 1 mg
Stemolecule™ Valproic   Acid 04-0007 5 g
Stemolecule™ WH-4-023 04-0079 2 mg
Stemolecule™ Wnt   Inhibitor IWP-2 04-0034 2 mg
Stemolecule™ Wnt   Inhibitor IWP-3 04-0035 2 mg
Stemolecule™ Wnt   Inhibitor IWP-4 04-0036 2 mg
Stemolecule™ XAV939 04-0046 2 mg
Stemolecule™ Y27632 04-0012 2 mg
04-0012-10 10 mg
Stemolecule™ Y27632   Dihydrochloride Hydrate 04-0012-H-10 10 mg
Stemolecule™ Y27632 in Solution 04-0012-02 2 mg (10 mM)

 

 

1.

Chen, S., Liu, Z., Lu, S., & Hu, B. (2019). EPEL promotes the migration and invasion of osteosarcoma cells by upregulating ROCK1. Oncology letters, 17(3), 3133-3140.【StemoleculeTM Y-27632】

2.

Zucchini, C., Manara, M. C., Cristalli, C., Carrabotta, M., Greco, S., Pinca, R. S., … & Gambarotti, M. (2019). ROCK2 deprivation leads to the inhibition of tumor growth and metastatic potential in osteosarcoma cells through the modulation of YAP activity. Journal of Experimental & Clinical Cancer Research, 38(1), 1-14. 【StemoleculeTM Y-27632】

3.

Cong, F., Hao, H., Hsieh, M. H. L., Jiang, X., Liu, J., & Ng, N. (2019). Cancer patient selection for administration of wnt signaling inhibitors using rnf43 mutation status. U.S. Patent Application No. 16/259,419.【StemoleculeTM Wnt Inhibitor IWP-2】

4.

Keller, G., & Craft, A. M. (2019). Keller G, Craft A M. Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue. U.S. Patent Application No. 15/977,536. 【StemoleculeTM CHIR99021】

5.

Sun, X., Fu, X., Du, M., & Zhu, M. J. (2018). Ex vivo gut culture for studying differentiation and migration of small intestinal epithelial cells. Open biology, 8(4), 170256.【StemoleculeTM DAPT】

6.

Gieseck III, R. L., Hannan, N. R., Bort, R., Hanley, N. A., Drake, R. A., Cameron, G. W., … & Vallier, L. (2014). Maturation of induced pluripotent stem cell derived hepatocytes by 3D-culture. PloS one, 9(1), e86372.【Stemolecule CHIR99021】

7.

Brick, D. J., Stover, A. E., Nethercott, H. E., Banuelos, M. G., & Schwartz, P. H. (2014). GMP4‐Compatible Production and Expansion of Human Neural Stem Cells. Neural Stem Cell Assays, 35-53. 【StemoleculeTM Y-27632】

8.

Fathi, A., Rasouli, H., Yeganeh, M., Salekdeh, G. H., & Baharvand, H. (2015). Efficient differentiation of human embryonic stem cells toward dopaminergic neurons using recombinant LMX1A factor. Molecular biotechnology, 57(2), 184-194. 【StemoleculeTM SB431542,StemoleculeTM LDN-193189】

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