N-Ras 抗体 (F155) N-Ras Antibody (F155)

N-Ras 抗体 (F155)

N-Ras Antibody (F155)

详细描述:
N-Ras Antibody (F155) is a high quality monoclonal N-Ras antibody (also designated NRAS antibody) suitable for the detection of the N-Ras protein of mouse, rat and human origin. N-Ras Antibody (F155) is available as the non-conjugated anti-N-Ras antibody. The mammalian Ras (also designated v-Ha-Ras, Harvey rat sarcoma viral oncogene homolog, HRAS1, K-Ras, N-Ras, RASH1 or c-bas/has) gene family consists of the Harvey and Kirsten Ras genes (c-H-Ras1 and c-K-Ras2), an inactive pseudogene of each (c-H-Ras2 and c-K-Ras1) and the N-Ras gene. The three Ras oncogenes, H-Ras, K-Ras and N-Ras, encode proteins with GTP/GDP binding and GTPase activity. Ras proteins alternate between an inactive form bound to GDP and an active form bound to GTP, activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Ras nomenclature originates from the characterization of human DNA sequences homologous to cloned DNA fragments containing oncogenic sequences of a type C mammalian retrovirus, the Harvey strain of murine sarcoma virus (HaMSV), derived from the rat. Under normal conditions, Ras family members influence cell growth and differentiation events in a subcellular membrane compartmentalization-based signaling system. Oncogenic Ras can deregulate processes that control both cell proliferation and apoptosis. The Ras superfamily of GTP hydrolysis-coupled signal transduction relay proteins can be subclassified into Ras, Rho, Rab and ARF families.

应用范围:WB, IP, IF, IHC(P);反应种属:mouse, rat, human;Isotype:mouse monoclonal IgG1;标记:未标记。

货号 产品名称 品牌 购买
货号 名称 单位 购买
sc-31 N-Ras 抗体 (F155) 100 µg/ml 咨询客服