iFluor 568 酪胺

	货号	45106	存储条件	在零下15度以下保存, 避免光照
	规格	200 Slides	价格	3648
	Ex (nm)	568	Em (nm)	587
	分子量	813.89	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：45106

产品名称：iFluor 568 酪胺

规格：200 Slides

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：813.89

Ex(nm)：568

Em(nm)：587

量子产率(cm ^-1 M ^-1)：100000

消光系数：0.57

产品介绍

对于许多免疫组织化学（IHC）的应用，传统的酶扩增程序足以实现充分的抗原检测。然而，有几个因素限制了这些程序的敏感性和实用性。酪胺信号放大技术（TSA）已被证明是一种特别通用和强大的酶放大技术，提高了检测灵敏度。TSA是基于HRP在低浓度过氧化氢存在下将标记的酪胺底物转化为氧化的、高活性的自由基的能力，该自由基可在HRP处或其附近共价结合酪氨酸残基。为了达到最大限度的IHC检测，酪胺预先标记了一个荧光团。通过每个过氧化物酶标签上的多个酪胺底物的转换所产生的信号放大转化为对低丰度目标的超灵敏检测，以及使用少量抗体和杂交探针。在免疫组化应用中，TSA法的敏感性增强使原代抗体稀释度增加，以减少非特异性背景信号，并能克服由于固定程序不理想或靶蛋白表达水平低而导致的弱免疫标记。iFluor 568酪胺含有明亮的iFluor568，可以很容易地用标准ROX滤波片组检测。它是Alexa Fluor®568酪胺（Alexa Fluor®是ThermoFisher的商标）或其他光谱类似的荧光酪胺共轭物或TSA试剂（如荧光素酪胺）的极好替代品。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的iFluor 568 酪胺。

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iFluor 594 酪胺

	货号	45107	存储条件	在零下15度以下保存, 避免光照
	规格	200 Slides	价格	3648
	Ex (nm)	588	Em (nm)	604
	分子量	841.95	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：45107

产品名称：iFluor 594 酪胺

规格：200 Slides

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：841.95

Ex(nm)：588

Em(nm)：604

量子产率(cm ^-1 M ^-1)：180000

消光系数：0.53

产品介绍

对于许多免疫组织化学（IHC）的应用，传统的酶扩增程序足以实现充分的抗原检测。然而，有几个因素限制了这些程序的敏感性和实用性。酪胺信号放大技术（TSA）已被证明是一种特别通用和强大的酶放大技术，提高了检测灵敏度。TSA是基于HRP在低浓度过氧化氢存在下将标记的酪胺底物转化为氧化的、高活性的自由基的能力，该自由基可在HRP处或其附近共价结合酪氨酸残基。为了达到最大限度的IHC检测，酪胺预先标记了一个荧光团。通过每个过氧化物酶标签上的多个酪胺底物的转换所产生的信号放大转化为对低丰度目标的超灵敏检测，以及使用少量抗体和杂交探针。在免疫组化应用中，TSA法的敏感性增强使原代抗体稀释度增加，以减少非特异性背景信号，并能克服由于固定程序不理想或靶蛋白表达水平低而导致的弱免疫标记。iFluor 594酪胺含有明亮的iFluor594，可以很容易地用标准Texas Red滤波片组检测。它是Alexa Fluor®594酪胺（Alexa Fluor®是ThermoFisher的商标）或其他光谱类似的荧光酪胺共轭物或TSA试剂（如荧光素酪胺）的极好替代品。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的iFluor 594 酪胺。

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雌二醇琥珀酰亚胺酯

	货号	50545	存储条件	在零下15度以下保存, 避免光照
	规格	1 mg	价格	1176
	Ex (nm)		Em (nm)
	分子量	456.50	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：50545

产品名称：雌二醇琥珀酰亚胺酯

规格：1mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：456.50

外观：固体

溶剂：DMSO

产品介绍

雌二醇是雌激素类固醇激素和主要的女性性激素。 它也被称为17β-雌二醇。 雌二醇参与发情和月经女性生殖周期的调节。 它负责女性次生性特征的发展，对女性生殖组织和妊娠的发展和维持很重要。 它还在许多其他组织（包括骨骼，脂肪，皮肤，肝脏和大脑）中具有重要作用。 尽管男性的雌二醇水平比女性低得多，但雌二醇在男性中也起着重要的作用。 雌二醇测试可测量血液中激素雌二醇的含量。 也称为E2测试。 雌二醇实验具有许多临床上重要的应用。雌二醇琥珀酰亚胺酯是开发雌二醇缀合物和检测方法的一个方便的基础。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的雌二醇琥珀酰亚胺酯。 

参考文献

A Gold(III) Pincer Ligand Scaffold for the Synthesis of Binuclear and Bioconjugated Complexes: Synthesis and Anticancer Potential.
Authors: Bertrand, Benoît and O’Connell, Maria A and Waller, Zoë A E and Bochmann, Manfred
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) (2018): 3613-3622

Efficient Synthesis of Glutamate Peptide-Estradiol Conjugate for Imaging Estrogen Receptor-Positive Diseases.
Authors: Shih, Ming-Chi and Simon, Sergio Daniel and Jin, Zhiming and Gui, Yuan and Xu, Bohua and Xu, Zhihong and Rosado-de-Castro, Paulo Henrique and Silveira Braghirolli, Ana Maria and Barbosa da Fonseca, Lea Mirian and Inoue, Tomio and Yang, David J
Journal: BioMed research international (2018): 5208964

Membrane-initiated estradiol signaling increases tyrosine hydroxylase promoter activity with ER alpha in PC12 cells.
Authors: Maharjan, Shreekrishna and Serova, Lidia I and Sabban, Esther L
Journal: Journal of neurochemistry (2010): 42-55

Bone selective effect of an estradiol conjugate with a novel tetracycline-derived bone-targeting agent.
Authors: Neale, Jason R and Richter, Natali B and Merten, Kevyn E and Taylor, K Grant and Singh, Sujan and Waite, Leonard C and Emery, Nicole K and Smith, Ned B and Cai, Jian and Pierce, William M
Journal: Bioorganic & medicinal chemistry letters (2009): 680-3

Estrogens exert a rapid apoptotic action in anterior pituitary cells.
Authors: Zárate, S and Jaita, G and Zaldivar, V and Radl, D B and Eijo, G and Ferraris, J and Pisera, D and Seilicovich, A
Journal: American journal of physiology. Endocrinology and metabolism (2009): E664-71

Picogram-detection of estradiol at an electrochemical immunosensor with a gold nanoparticle|Protein G-(LC-SPDP)-scaffold.
Authors: Liu, Xiaoqiang and Wong, Danny K Y
Journal: Talanta (2009): 1437-43

An estradiol-conjugate for radiolabelling with 177Lu: an attempt to prepare a radiotherapeutic agent.
Authors: Banerjee, Sharmila and Das, Tapas and Chakraborty, Sudipta and Samuel, Grace and Korde, Aruna and Venkatesh, Meera and Pillai, M R A
Journal: Bioorganic & medicinal chemistry (2005): 4315-22

Macromolecular prodrugs XI. Synthesis and characterization of polymer-estradiol conjugate.
Authors: Zovko, M and Zorc, B and Novak, P and Tepes, P and Cetina-Cizmek, B and Horvat, M
Journal: International journal of pharmaceutics (2004): 35-41

Engineering receptors and antibodies for biosensors.
Authors: Hock, B and Seifert, M and Kramer, K
Journal: Biosensors & bioelectronics (2002): 239-49

Some new aspects of 17alpha-estradiol metabolism in man.
Authors: Hobe, Gerhard and Schön, Renate and Goncharov, Nikolai and Katsiya, Gulnara and Koryakin, Mikhail and Gesson-Cholat, Isabelle and Oettel, Michael and Zimmermann, Holger
Journal: Steroids (2002): 883-93

雌二醇马来酰亚胺

	货号	50547	存储条件	在零下15度以下保存, 避免光照
	规格	1 mg	价格	2412
	Ex (nm)		Em (nm)
	分子量	481.55	溶剂	DMSO
	产品详细介绍

简要概述

产品基本信息

货号：50547

产品名称：雌二醇马来酰亚胺

规格：1mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

分子量：481.55

外观：固体

溶剂：DMSO

产品介绍

雌二醇是雌激素类固醇激素和主要的女性性激素。 它也被称为17β-雌二醇。 雌二醇参与发情和月经女性生殖周期的调节。 它负责女性次生性特征的发展，对女性生殖组织和妊娠的发展和维持很重要。 它还在许多其他组织（包括骨骼，脂肪，皮肤，肝脏和大脑）中具有重要作用。 尽管男性的雌二醇水平比女性低得多，但雌二醇在男性中也起着重要的作用。 雌二醇测试可测量血液中激素雌二醇的含量。 也称为E2测试。 雌二醇实验具有许多临床上重要的应用。雌二醇马来酰亚胺是开发雌二醇缀合物和检测方法的一个方便的基础。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的雌二醇马来酰亚胺。 

参考文献

17β-Estradiol as a New Therapy to Preserve Microcirculatory Perfusion in Small Bowel Donors.
Authors: Vieira, Roberta Figueiredo and Breithaupt-Faloppa, Ana Cristina and Correia, Cristiano de Jesus and Armstrong, Roberto and Silva, Raphael Dos Santos Coutinho E and Ferreira, Sueli Gomes and Moreira, Luiz Felipe Pinho and Sannomiya, Paulina
Journal: Transplantation (2020)

17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.
Authors: Esmailidehaj, Mansour and Kuchakzade, Fatemeh and Rezvani, Mohammad Ebrahim and Farhadi, Zeinab and Esmaeili, Hassan and Azizian, Hossein
Journal: Life sciences (2020): 117673

17β-estradiol attenuates rat articular chondrocyte injury by targeting ASIC1a-mediated apoptosis.
Authors: Song, Su-Jing and Tao, Jing-Jing and Li, Shu-Fang and Qian, Xue-Wen and Niu, Ruo-Wen and Wang, Cong and Zhang, Yi-Hao and Chen, Yong and Wang, Ke and Zhu, Fei and Zhu, Chuan-Jun and Ma, Gang-Gang and Yang-Yang and Peng, Xiao-Qing and Zhou, Ren-Peng and Chen, Fei-Hu
Journal: Molecular and cellular endocrinology (2020): 110742

A self-powered photoelectrochemical cathodic aptasensor for the detection of 17β-estradiol based on FeOOH/In2S3 photoanode.
Authors: Li, Yuewen and Liu, Lei and Feng, Jinhui and Ren, Xiang and Zhang, Yong and Yan, Tao and Liu, Xuejing and Wei, Qin
Journal: Biosensors & bioelectronics (2020): 112089

Advanced oxidative processes in the degradation of 17β-estradiol present on surface waters: kinetics, byproducts and ecotoxicity.
Authors: Perondi, Taise and Michelon, William and Junior, Paulo Reis and Knoblauch, Priscila M and Chiareloto, Marilete and de Fátima Peralta Muniz Moreira, Regina and Peralta, Rosely Aparecida and Düsman, Elisângela and Pokrywiecki, Ticiane Sauer
Journal: Environmental science and pollution research international (2020)

Aloe/poloxamer hydrogel as an injectable β-estradiol delivery scaffold with multi-therapeutic effects to promote endometrial regeneration for intrauterine adhesion treatment.
Authors: Yao, Qing and Zheng, Ya-Wen and Lan, Qing-Hua and Wang, Li-Fen and Huang, Zhi-Wei and Chen, Rui and Yang, Yang and Xu, He-Lin and Kou, Longfa and Zhao, Ying-Zheng
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2020): 105316

Association between 17-β-estradiol and IL-8 and visual field progression in postmenopausal women with primary angle closure glaucoma.
Authors: Li, Shengjie and Zhang, Haichen and Shao, Mingxi and Li, Yingzhu and Song, Yunxiao and Sun, Xinghuai and Cao, Wenjun
Journal: American journal of ophthalmology (2020)

Atogepant Has No Clinically Relevant Effects on the Pharmacokinetics of an Ethinyl Estradiol/Levonorgestrel Oral Contraceptive in Healthy Female Participants.
Authors: Ankrom, Wendy and Xu, Jialin and Vallee, Marie-Helene and Dockendorf, Marissa F and Armas, Danielle and Boinpally, Ramesh and Min, K Chris
Journal: Journal of clinical pharmacology (2020)

Beta-estradiol protects against copper-ascorbate induced oxidative damage in goat liver mitochondria in vitro by binding with ascorbic acid.
Authors: Ghosh, Arnab K and Bhattacharjee, Bharati and Mishra, Sanatan and Roy, Souvik and Chattopadhyay, Aindrila and Banerjee, Adrita and Bandyopadhyay, Debasish
Journal: Life sciences (2020): 117596

Changes in serum estradiol levels with Estring in postmenopausal women with breast cancer treated with aromatase inhibitors.
Authors: Streff, Alyssa and Chu-Pilli, Michele and Stopeck, Alison and Chalasani, Pavani
Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2020)

雌二醇-KLH缀合物

	货号	50554	存储条件	在零下15度以下保存, 避免光照
	规格	5 mg	价格	6120
	Ex (nm)		Em (nm)
	分子量		溶剂	Water
	产品详细介绍

简要概述

产品基本信息

货号：50554

产品名称：雌二醇-KLH缀合物

规格：5mg

储存条件：-15℃避光防潮

保质期：12个月

产品物理化学光谱特性

外观：固体

溶剂：水

产品介绍

雌二醇是雌激素类固醇激素和主要的女性性激素。 它也被称为17β-雌二醇。 雌二醇参与发情和月经女性生殖周期的调节。 它负责女性次生性特征的发展，对女性生殖组织和妊娠的发展和维持很重要。 它还在许多其他组织（包括骨骼，脂肪，皮肤，肝脏和大脑）中具有重要作用。 尽管男性的雌二醇水平比女性低得多，但雌二醇在男性中也起着重要的作用。 雌二醇测试可测量血液中激素雌二醇的含量。 也称为E2测试。 雌二醇实验具有许多临床上重要的应用。雌二醇-KLH缀合物是开发雌二醇缀合物和检测方法的一个方便的基础。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的雌二醇-KLH缀合物。 

参考文献

Effects of cyclic versus sustained estrogen administration on peripheral immune functions in ovariectomized mice.
Authors: Li, Jing and McMurray, Robert W
Journal: American journal of reproductive immunology (New York, N.Y. : 1989) (2010): 274-81

Effects of estrogen receptor subtype-selective agonists on immune functions in ovariectomized mice.
Authors: Li, Jing and McMurray, Robert W
Journal: International immunopharmacology (2006): 1413-23

Development of monoclonal antibodies to 4-hydroxyestrogen-2-N-acetylcysteine conjugates: immunoaffinity and spectroscopic studies.
Authors: Markushin, Y and Kapke, P and Saeed, M and Zhang, H and Dawoud, A and Rogan, E G and Cavalieri, E L and Jankowiak, R
Journal: Chemical research in toxicology (2005): 1520-7

Role of putative membrane receptors in the effects of estradiol on human vascular cell growth.
Authors: Somjen, Dalia and Kohen, Fortune and Gayer, Batya and Sharon, Orly and Baz, Merav and Limor, Rona and Kulik, Tikva and Knoll, Esther and Stern, Naftali
Journal: American journal of hypertension (2004): 462-9

Social interactions differentially affect reproductive and immune responses of Siberian hamsters.
Authors: Demas, Gregory E and Johnson, Corey and Polacek, Kelly M
Journal: Physiology & behavior (2004): 73-9

Social interactions unmask sex differences in humoral immunity in voles.
Authors: Klein and Nelson
Journal: Animal behaviour (1999): 603-610

Distribution of rat hepatic steroid 5 alpha-reductase 1 as shown by immunohistochemistry.
Authors: Eicheler, W and Seitz, J and Steinhoff, M and Forssmann, W G and Adermann, K and Aumüller, G
Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (1995): 105-12

Testis function and feedlot performance of bulls actively immunized against gonadotropin-releasing hormone: effect of implants containing progesterone and estradiol benzoate.
Authors: Adams, T E and Daley, C A and Adams, B M and Sakurai, H
Journal: Journal of animal science (1993): 811-7

Pattern of gonadotropin-releasing hormone (GnRH)-like stimuli sufficient to induce follicular growth and ovulation in ewes passively immunized against GnRH.
Authors: Sakurai, H and Adams, B M and Adams, T E
Journal: Biology of reproduction (1992): 177-84

Gonadotrope function in ovariectomized ewes actively immunized against gonadotropin-releasing hormone (GnRH).
Authors: Adams, T E and Adams, B M
Journal: Biology of reproduction (1986): 360-7

ReadiLink™xtra Rapid iFluor™488抗体标记试剂盒（标记50ug抗体）

	货号	1955	存储条件	在零下15度以下保存, 避免光照
	规格	2 Labelings	价格	2412
	Ex (nm)	491	Em (nm)	516
	分子量		溶剂
	产品详细介绍

简要概述

ReadiLink™xtra快速抗体标记试剂是AAT 研发，由金畔代理销售的iFluor488标记的抗体标记试剂盒。ReadiLink™xtra快速抗体标记试剂盒基本上只需要2个简单的混合步骤，而无需纯化。ReadiLink™试剂盒中使用的预活化iFluor™488非常稳定，对抗体表现出良好的反应性和选择性。该试剂盒具有用于标记〜2×50 ug抗体的所有基本成分。试剂盒中提供的两个预活化iFluor™488染料小瓶中的每一个均经过优化，可标记约50 µg抗体。ReadiLink™xtra iFluor™488快速抗体标记试剂盒提供了一种方便而强大的方法，可以使用绿色的iFluor™488荧光团标记单克隆和多克隆抗体。金畔生物是AAT Bioquest的中国代理商，为您提供最优质的抗体标记试剂盒。 

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产品说明书